Hematopoietic Stem Cells

Hematopoietic stem cells are responsible for the production and replenishment of all blood cell types during the entire life of an organism. HSCs are first generated during embryonic development and then colonize in the bone marrow where they will reside in adults. HSC therapy is the current standard treatment for numerous hematological conditions such as multiple myeloma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, and sickle cell anemia. HSCs will rapidly expand after in vivo transplantation, however, control of HSC self-renewal and differentiation in culture remains difficult.